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Questions on specific products

What are the possible causes of such a severe adverse reaction of the organism of the volunteers in the case of TGN1412?

Can something similar happen in the Czech Republic?

TGN1412 belongs to the group of monoclonal antibodies. Are any medicines using monoclonal antibodies being tested in the Czech Republic?

What is the actual mechanism of action of monoclonal antibodies? Do they stimulate the immune system or do they act as a means which transports the pharmaceutical to the affected tissue?

Have you seen any cases when the tested substances were given to patients without the patients being aware of it?